Sinemet CR
Sinemet CR is carbidopa with levodopa 25/100mg in a modified-release tablet for Parkinson's disease, spreading the dose across a longer period.
All strengths and pack prices
| Strength | Pack | Price | Per unit |
|---|---|---|---|
| 25/100mg | 30 tablets | $39.90 | $1.33 |
| 25/100mg | 60 tablets | $66.60 | $1.11 |
| 25/100mg | 90 tablets | $89.10 | $0.99 |
| 25/100mg | 120 tablets | $110.40 | $0.92 |
| 25/100mg | 180 tablets | $149.40 | $0.83 |
| 25/100mg | 360 tablets | $277.20 | $0.77 |
- Condition
- Parkinson's Disease
- Alternative names
- Sinemet; Caramet; Duodopa
- Therapeutic class
- Dopamine Precursor / Dopa Decarboxylase Inhibitor
- Pharmacological class
- Dopaminergic Agent
- Minor side effects
- nausea; dizziness; dry mouth
- Moderate side effects
- involuntary movements; confusion; orthostatic hypotension
- Dosage forms
- Modified-release tablet
- Administration route
- Oral use
- Originator
- MSD
- Onset time
- 30–90 minutes
- Duration
- 4–6 hours
- Storage instructions
- Store below 25°C, keep container closed.
- Drug interactions
- iron supplements; antipsychotics
- Age restrictions
- Not recommended for children.
- Pregnancy and breastfeeding
- Pregnancy: Consult healthcare professional. Breastfeeding: Avoid administration.
Contraindications
hypersensitivity to components; narrow-angle glaucoma; concurrent use of non-selective maois
Precautions and warnings
may cause sudden sleep onset; monitor for impulse control disorders; avoid rapid discontinuation
Serious side effects
hallucinations, requires immediate medical attention; malignant syndrome, requires immediate medical attention
Patient summary
Sinemet CR is carbidopa with levodopa 25/100mg in a modified-release tablet for Parkinson's disease, spreading the dose across a longer period.
Mechanism of action
Sinemet CR combines levodopa, which crosses the blood-brain barrier to be converted into dopamine, and carbidopa, which prevents periphery metabolism of levodopa. This allows more active substance to reach the brain to improve movement control.
Sinemet CR combines carbidopa and levodopa for the management of Parkinson’s Disease. This therapeutic formula is also sold under brand names including Sinemet, Caramet and Duodopa. It is supplied as a tablet in a 25/100mg strength.
Buying Sinemet CR
Generic carbidopa and levodopa provides a far more affordable option compared to the original brand, helping expats and residents secure consistent access to their regular maintenance medication.
What you will receive
Sinemet CR is the originator brand name, made by MSD. We use it here to identify the medicine only; we are not affiliated with MSD and do not ship the original Sinemet CR.
- You receive a generic equivalent: the same active ingredient (Carbidopa / Levodopa) at the same dose, mostly recognised branded generics from vetted manufacturers.
- The exact brand supplied depends on what is in stock at the dispatching warehouse.
- Inactive ingredients, tablet appearance and packaging can differ from the original brand; the active ingredient and dose are the same.